Coach Deion Sanders and the Colorado Buffaloes will try to bounce back from their first loss of the season when they host the No. 8 USC Trojans in a Pac-12 game on Saturday at Folsom Field in Boulder, Co. After wins over TCU, Nebraska and Colorado State to start the season, the Buffaloes were the talk of college football. But last week Colorado (3-1, 0-1 in Pac-12) was blown out by Oregon, 42-6. Meanwhile the Trojans (4-0, 2-0) have cruised in their four games this season, winning by an average of 35.0 points per game. 

Kickoff is scheduled for noon ET. The Trojans are 22.5-point favorites in the latest USC vs. Colorado odds, while the over/under for total points scored is 73. USC is the -1527 favorite on the money line, while Colorado is +843 (see up-to-date odds for every game this week on our college football odds page.)

Before you make any Colorado vs. USC picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns!

The model knows that the Trojans have arguably the best player in the country, quarterback Caleb Williams. The reigning Heisman Trophy winner, Williams leads the country in yards per pass attempt (11.88), points responsible for per game (27.5), passing efficiency (223.1) and points responsible for (110). He also ranks second in passing touchdowns (15) and 10th in passing yards per completion (16.0).

The model also knows that the Buffaloes have one of the best passing attacks in the country. Led by quarterback Shedeur Sanders, Colorado ranks fifth in passing yards per game (353.2). Sanders has been the catalyst of the attack, completing 76.9% of his passes, which ranks fifth in the country.

Now, the model has set its sights on USC vs. Colorado. We can tell you it is leaning Under the total, projecting the teams to combine for 69 points, and it also says one side of the spread hits in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Colorado vs. USC? And which side of the spread hits in well over 50% of simulations? ... Join SportsLine right now to find out which side of the USC vs. Colorado spread you should be all over Saturday, all from the model that's up nearly $2,500 on top-rated CFB spread picks since its inception!