Lightweight champion Islam Makhachev defends his title Saturday against top-rated challenger Arman Tsarukyan in the main event of UFC 311. The main card is set for 10 p.m. ET from the Intuit Dome in Inglewood, Calif.

Makhachev is a -350 favorite (risk $350 to win $100), while Tsarukyan is priced at +275 (risk $100 to win $275) in the latest MMA odds for UFC 311: Makhachev vs. Tsarukyan 2. 

Before making any UFC 311 picks, make sure you see the MMA predictions and betting advice from SportsLine expert Daniel Vithlani. 

Vithlani is a highly analytical UFC bettor who has been a consistent winner for SportsLine members since making his debut in January 2023 with a 5-0 record for UFC 283. In fact, he's up over $1,500 on his UFC main-card picks!

His other highlights include calling an upset for Sean O'Malley (+210) against Aljamain Sterling (-250) at UFC 292 as part of a 4-1 main card and his UFC 299 winners included underdog selections on Dustin Poirier (+190) against Benoit Saint Denis (-230) and Michael Page (+110) against Kevin Holland (-130). Anyone who has followed him could be way up.

This week at UFC 311: Makhachev vs. Tsarukyan 2, we can tell you Vithlani is backing Diego Ferreira (+210) to defeat Grant Dawson (-260) in a lightweight matchup on the preliminary card.

Vithlani has strong picks for Makhachev vs. Tsarukyan  and other bouts on the UFC 311 card. He's also backing a fighter whose "unmatched cardio and pace" will lead the way to a massive victory! You ABSOLUTELY need to see his UFC 311 picks before making any of your own!

Who wins UFC 311: Makhachev vs. Tsarukyan 2, and which fighter is a MUST-BACK? Join SportsLine now to see which fighters you need to be all over, all from the expert who profited more than $1,500 on UFC main-card picks!