Bantamweight champion Sean O'Malley makes his second title defense Saturday against top-ranked challenger Merab Dvalishvili in the main event of UFC 306 in Las Vegas. The main card is set for 10 p.m. ET from the Sphere, for what is expected to be a one-time event at the celebrated new venue. 

O'Malley is a -125 favorite (risk $125 to win $100), while Dvalishvili is priced at +105 (risk $100 to win $105) in the latest MMA odds for UFC 306: O'Malley vs. Dvalishvili. Before locking in your picks for UFC 306: O'Malley vs. Dvalishvili, make sure you see the MMA predictions and betting advice from SportsLine expert Daniel Vithlani. 

Vithlani is a highly analytical UFC bettor who has been a consistent winner for SportsLine members since making his debut in January 2023 with a 5-0 record for UFC 283. In fact, he's up over $1,500 on his UFC main-card picks!

His other highlights include calling an upset for Sean O'Malley (+210) against Aljamain Sterling (-250) at UFC 292 as part of a 4-1 main card and his UFC 299 winners included underdog selections on Dustin Poirier (+190) against Benoit Saint Denis (-230) and Michael Page (+110) against Kevin Holland (-130). Anyone who has followed him is WAY UP!

This week at UFC 306: O'Malley vs. Dvalishvili, we can tell you Vithlani is backing Daniel Zellhuber (-190) to get the victory over Esteban Ribovics (+160) in a lightweight match

Vithlani has strong picks for O'Malley vs. Dvalishvili and other bouts on the UFC 306 card. He's also backing a fighter who is "extremely active and continually improving!" You ABSOLUTELY need to see his UFC 306 picks before making any of your own!

Who wins UFC 306: O'Malley vs. Dvalishvili and which fighter is a MUST-BACK? Join SportsLine now to see which fighters you need to be all over, all from the expert who profited more than $1,500 on UFC main-card picks!