Already the only two-time UFC Middleweight Champion, Israel Adesanya will go for his third title reign at UFC 305 against champion Dricus du Plessis. The main card for UFC 305: du Plessis vs. Adesanya is set for 10 p.m. ET from the RAC Arena in Perth, Australia. Adesanya is the -120 favorite (risk $120 to win $100) in the latest UFC 305 odds, with de Plessis the +100 underdog.

Other bouts on the UFC 305 card include top-10 flyweights tangling with Kai Kara-France (+160) vs. Steve Erceg (-190) and a lightweight bout featuring Mateusz Gamrot (-440) vs. Dan Hooker (+340). Before locking in your picks for UFC 305: du Plessis vs. Adesanya or entering any UFC props on sites like PrizePicks, Underdog Fantasy, or Sleeper Fantasy, make sure you see the MMA predictions and betting advice from SportsLine expert Daniel Vithlani.

Vithlani is a highly analytical UFC bettor who has been a consistent winner for SportsLine members since making his debut in January 2023 with a 5-0 record for UFC 283. In fact, he's up over $1,200 on his UFC main-card picks!

His other highlights include calling an upset for Sean O'Malley (+210) against Aljamain Sterling (-250) at UFC 292 as part of a 4-1 main card and his UFC 299 winners included underdog selections on Dustin Poirier (+190) against Benoit Saint Denis (-230) and Michael Page (+110) against Kevin Holland (-130). Anyone who has followed him is WAY UP!

This week at UFC 305: du Plessis vs. Adesanya, we can tell you Vithlani is backing Jairzinho Rozenstruik (-250) to get the win over Tai Tuivasa in a heavyweight clash on the main card. "Rozenstruik throws a clean jab, hard low kicks, and can mix in a sneaky head kick. He is patient and very intelligent at range. Tuivasa's best chance is to rush Rozenstruik with a blitz of punches, and catch him with a looping shot. While that certainly is possible, I feel Tuivasa has sustained too much damage to trust, against a measured striker like Rozenstruik," Vithlani told SportsLine.

Vithlani has strong picks for du Plessis vs. Adesanya and other bouts on the UFC 305 card. He's also backing an underdog who "is the much more dangerous striker" to emerge with a HUGE victory! You ABSOLUTELY need to see his UFC 305 picks before making any of your own!

Who wins at UFC 305: du Plessis vs. Adesanya, and which fighter is a MUST-BACK? Join SportsLine now to see which fighters you need to be all over, all from the expert who profited more than $1,200 on UFC main-card picks!