Middleweight champion Israel Adesanya defends his belt against fourth-ranked contender Alex Pereira on Saturday in the main event of UFC 281. The main UFC 281 fight card is set for 10 p.m. ET from Madison Square Garden in New York City.

Adesanya is a -230 favorite (risk $230 to win $100), while Pereira is priced at +190 (risk $100 to win $190) in the latest Caesars Sportsbook MMA odds for UFC 281: Adesanya vs. Pereira.  

Before finalizing any UFC 281: Adesanya vs. Pereira picks of your own, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley. Over the past three-plus years, $100 bettors who have followed Marley's picks are up more than $13,000! 

The accomplished MMA analyst has provided consistent winners for SportsLine members for the past three-plus years. His accomplishments include hitting five consecutive main-event underdog winners in 2020 following the UFC's brief pause in action because of the pandemic. Anyone who has followed Marley is WAY UP!

This week at UFC 281: Adesanya vs. Pereira, we can tell you Marley is backing Dominick Reyes (-220) to get past Ryan Spann (+180) in a battle of light heavyweight contenders on the preliminary card. 

Marley also has strong picks for Adesanya vs. Pereira and every other bout on the UFC 281 card. He's also backing a fighter who "will dominate in the striking" to emerge with a huge victory! You MUST SEE his UFC 281 picks before making any of your own.

Who wins UFC 281: Adesanya vs. Pereira? Join SportsLine now to see which fighters you need to be all over Saturday, all from the expert who's up more than $13,000 on MMA picks!