The vacant lightweight title is on the line Saturday in the main event of UFC 280 when top-ranked Charles Oliveira takes on No. 4-ranked contender Islam Makhachev. The main card is set for 2 p.m. ET from Etihad Arena in Abu Dhabi.

Makhachev is a -190 favorite (risk $190 to win $100), while Oliveira is priced at +170 (risk $100 to win $170) in the latest Caesars Sportsbook MMA odds for UFC 280: Oliveira vs. Makhachev.  

Before finalizing any UFC 280: Oliveira vs. Makhachev picks of your own, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley. Over the past three-plus years, $100 bettors who have followed Marley's picks are up more than $13,000! 

The accomplished MMA analyst has provided consistent winners for SportsLine members for the past three-plus years. His accomplishments include hitting five consecutive main-event underdog winners in 2020 following the UFC's brief pause in action because of the pandemic. Anyone who has followed Marley is WAY UP!

This week at UFC 280: Oliveira vs. Makhachev, we can tell you Marley is siding with Beneil Dariush (+165) to get past Mateusz Gamrot (-185) in a clash of lightweight contenders on the main card.

Marley also has strong picks for Oliveira vs. Makhachev and every other bout on the UFC 280 card. He's also backing a fighter who "is the better and more dangerous striker" to emerge with an upset victory! You MUST SEE his UFC 280 picks before making any of your own.

Who wins UFC 280: Oliveira vs. Makhachev? which fighters you need to be all over Saturday, all from the expert who's up more than $13,000 on MMA picks!