The first UFC pay-per-view event of 2022 features two popular heavyweights, as undisputed champion Francis Ngannou takes on interim champion Ciryl Gane in the main event. The main card is set for 10 p.m. ET from the Honda Center in Anaheim.

Gane is a -160 betting favorite (risk $160 to win $100), while Ngannou is priced at +140 (risk $100 to win $140) in the latest Ngannou vs. Gane odds at Caesars Sportsbook. 

Before making any UFC 270: Ngannou vs. Gane picks of your own, make sure you check out the MMA predictions and betting advice from SportsLine expert Andrew Gombas. 

Gombas is a former NCAA wrestler who taps into his experience on the mat to help understand and dissect the X's and O's of MMA matchups in a manner that sets him apart from other MMA analysts. He started the MMA handicapping service MMA Knockout Bets in 2018 and has shown a profit every year since.

With more than 1,400 selections tracked by the third-party monitoring service Bet MMA, he has shown a 6 percent return on investment for his followers. Over the past two years, his followers have netted a profit of more than $10,000!

Just last week, Gombas kicked off the 2022 UFC season with a 6-2 record at UFC Fight Night that included a massive underdog winner on Calvin Kattar (+200) against Giga Chikadze (-240) in the main event.. Anyone who has followed Gombas is WAY UP! 

Now, he has locked in on the UFC 270 from every angle and released his top selections. A successful parlay of these picks would result in a payout of more than 16-1!

For UFC 270: Ngannou vs. Gane, we can tell you Gombas is backing Cody Stamann (+170) to pull the upset of Said Nurmagomedov (-190) in a showdown of bantamweight prospects. He's also backing a fighter to "utilize a jab and leg kicks" to earn a dominant victory! You ABSOLUTELY need to see his picks before locking in any UFC 270 selections of your own.

Who wins Ngannou vs. Gane? And which fighter is a MUST-BACK? ... Join SportsLine right now to see which fighters you need to be all over at UFC Fight Night, all from the MMA insider who returned a profit of more than $10,000 over the past two years!