Alexander Volkanovski will make the second defense of his featherweight belt on Saturday against top-ranked contender Brian Ortega in the main event of UFC 266. The main UFC 266 fight card is set for 10 p.m. ET from T-Mobile Arena in Las Vegas.

Volkanovski (22-1) is a five-year UFC veteran whose lone professional MMA defeat came more than eight years ago. He defeated celebrated former champion Max Holloway to take the title and also won a disputed split decision against Holloway in a rematch last year.

Now, he moves on to face the dangerous Ortega (15-1-1), who has long been hailed as a future champion, but was turned away by Holloway in lopsided fashion in his first title bid in December 2018. Injuries and other setbacks have delayed his career, but he is still getting another title shot.

Volkanovski is a -155 favorite (risk $155 to win $100), while Ortega is the +135 underdog (risk $100 to win $135) in the latest UFC 266 odds at Caesars Sportsbook. 

Before making any UFC 266 picks of your own, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley. Over the past 31 months, $100 bettors who have followed Marley's picks are up more than $14,000!

The accomplished MMA analyst has seen memorable run in 2020 carry over into 2021. He has now nailed 36 of his last 60 UFC main-event picks, a stretch that included a streak of five consecutive underdogs in 2020! Just last week at UFC Fight Night, he told SportsLine members to back Anthony Smith (-165) against Ryan Spann (+145) in the light heavyweight main event. Anyone who has followed Marley is WAY UP! 

This week at UFC 266 featuring Volkanovski vs. Ortega, we can tell you Marley is backing Nick Diaz (+130) to get his hand raised against Robbie Lawler (-150) in a middleweight matchup. He's also backing a fighter who will "dominate from the opening bell" to earn a lopsided victory! You ABSOLUTELY need to see Marley's other UFC 266 picks before making any of your own.

Who wins Volkanovski vs. Ortega and every bout on the UFC 266? And which fighter is a MUST-BACK? ... Join SportsLine right now to see which fighters you need to be all over Saturday, all from the expert who's up more than $14,000 on MMA picks!