Mixed martial arts megastar Conor McGregor returns to the Octagon on Saturday against former interim champion Dustin Poirier in the main event of UFC 257. The main UFC fight card is set for 10 p.m. ET. McGregor is a -340 favorite (risk $340 to win $100), while Poirier is a +275 underdog in the latest Poirier vs. McGregor odds at William Hill Sportsbook. 

Before making any picks for UFC 256, you NEED to see the UFC predictions from SportsLine MMA expert Brandon Wise. He specializes in picking main-card fights for UFC, which has enabled him to be profitable every year! In fact, Wise went a perfect 5-0 at UFC 239 and was 4-1 at both UFC 245 and UFC 249. He also nailed Khabib Nurmagomedov's destruction of Conor McGregor in 2018, Stipe Miocic's defeat of Daniel Cormier, Max Holloway's downfall in 2019 and Gaethje's TKO victory over Tony Ferguson in May. 

Since the UFC returned following a period of inactivity due to the coronavirus pandemic, Wise has gone 64-35-2 while nailing the method of victory 46 times!  At UFC 256, Wise  went 4-0-1 (the main event was a draw) and correctly nailed the method of victory in three of those winners! Those selections included calling a decision victory for Charles Oliveira (+145) against Tony Ferguson (-165) in the lightweight co-main event. Nay

For UFC 256, we can tell you Wise is backing Jessica Eye (+105) to upset Joanne Calderwood (-125) in a matchup of women's flyweight contenders. He's also backing one fighter to take control early and come away with an epic submission! You ABSOLUTELY need to see Wise's picks before making any of your own!

Who wins Poirier vs. McGregor 2 and every bout on Saturday's main UFC 257 card? And how exactly does each fight end? ... Join SportsLine here to see which fighters you need to be all over at UFC 257, all from the accomplished MMA analyst who has been profitable for six straight years!