Former two-division champion Conor McGregor returns to the cage Saturday against former interim champion Dustin Poirier in the main event of UFC 257. The main card from Fight Island is set for 10 p.m. ET. McGregor is a -340 favorite (risk $340 to win $100), while Poirier is a +275 underdog in the latest Poirier vs. McGregor odds at William Hill Sportsbook. 

Before making any UFC 257 picks of your own, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley.

Over the past 23 months, $100 bettors who have followed Marley's picks are up more than $22,000. The accomplished MMA analyst is coming off a memorable run in 2020 that saw him nail 24 of his last 34 UFC main event picks, a stretch that included a streak of five consecutive underdogs!

Marley started 2021 by picking up where he left off in 2020. The MMA analyst told SportsLine members to back former featherweight champ Max Holloway (-160) against Calvin Kattar (+140) in the main event. Holloway won a unanimous decision in spectacular fashion to give his followers another easy winner. Anyone who has followed Marley is WAY UP! 

This week for UFC 257, we can tell you Marley is backing Amanda Ribas (-320) to defeat Marina Rodriguez (+260) in a battle of ranked women's strawweights. He's also backing one fighter who "is more dangerous on his feet and on the mat" to get a TKO victory! You ABSOLUTELY need to see Marley's picks before making any of your own!

Who wins Poirier vs. McGregor 2 and every bout on the UFC 257 card? And which fighter is a must-back? ... Join SportsLine right now to see which fighters you need to be all over Saturday, all from the expert who's up more than $22,000 on MMA picks and has nailed a whopping 24 of the last 34 main events!