Italy puts its record 37-game unbeaten streak on the line on Wednesday when it takes on Spain in the UEFA Nations League semifinals at the San Siro in Milan, Italy. Kickoff is set for 2:45 p.m. ET. 

Caesars Sportsbook lists Italy as the +125 favorite (risk $100 to win $125) in its latest Italy vs. Spain odds, with Spain the +250 underdog. A draw is priced at +210 and the over-under for total goals scored is set at 2.5. (For the latest soccer news and analysis, click here)

Proven soccer expert Martin Green has identified his best bets for the Italy vs. Spain matchup below, and bettors who have followed his advice have cashed in huge. Green is a handicapper who has covered the game worldwide, and his European soccer picks have generated more than $36,000 for $100 bettors since the 2017-18 season.

Italy won Euro 2020 in a shootout against England in July and has won 14 of its last 18 matches. The Azzurri also beat Spain in a shootout in the semifinals at Euros. The Italians are stronger on defense, and with both teams being without key forwards -- and Spain already lacking bite in its attack -- the Azzurri back line could make the difference. The all-time series is tied 3-7-3 in official competitions.          

Spain dominates possession with its midfield of Sergio Busquets, Koke and Pedri, and it held the ball for 71 percent of the meeting at Euro 2020. Ferran Torres and Mikel Oyarzabal are able scorers in pace of striker Alvaro Morata, who is out with injury and had been under fire because of his struggles to finish. Italy's 5-0 rout of Lithuania last time out was its first win in 90 minutes in five matches.    

Green has broken down the Italy vs. Spain matchup from all sides, and he is going Under on the goal total. He provides a CONFIDENT best bet with a plus-money payout and has a full breakdown of the match! You ABSOLUTELY need to see his picks and analysis before making any selections of your own.

What are the best bets you can make on the Italy vs. Spain match on Wednesday? ... Join SportsLine now to see Martin Green's best bets on Wednesday's Italy vs. Spain matchup, all from the soccer insider who's generated more than $36,000 for $100 bettors since the 2017-18 season!