The 11th-ranked UConn Huskies will look to win their seventh game in a row when they take on the DePaul Blue Demons in a Big East Conference matchup on New Year's Day. UConn is coming off a 78-74 win at Butler on Dec. 21, while DePaul defeated Loyola Maryland 84-65 on Saturday. The Huskies (10-3, 2-0 Big East), who are 2-0 on the road, have won 18 games in a row against DePaul. The Blue Demons (9-4, 0-2 Big East), who have lost four of their last six games, are 9-1 on their home floor in 2024-25.

Tip-off from Wintrust Arena in Chicago is set for 2 p.m. ET on CBS Sports Network. UConn is an 11-point favorite in the latest UConn vs. DePaul odds from SportsLine consensus, while the over/under for total points scored is 145.5. Before entering any UConn vs. DePaul picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 9 of the 2024-25 season on a 183-130 roll (+2520) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

The model has simulated UConn vs. DePaul 10,000 times and the results are in. We can tell you that the model is leaning Over and it's also generated a point-spread pick that is hitting well over 70% of the time!

So who wins UConn vs. DePaul? And which side of the spread hits well over 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!