Oleksandr Usyk will defend his three major heavyweight belts in a rematch against former champion Tyson Fury on December 21. The main card is set for 2 p.m. ET from Kingdom Arena in Riyadh, Saudi Arabia.

Usyk is a -170 favorite (risk $170 to win $100), while Fury is priced at +140 (risk $100 to win $140) in the latest boxing odds for Tyson Fury vs. Oleksandr Usyk 2. Before locking in your Tyson Fury vs. Oleksandr Usyk 2 picks, you NEED to see the boxing predictions and betting advice from SportsLine analyst Josh Nagel.  

Nagel, who is the combat sports editor for SportsLine, is an experienced and successful boxing analyst. He previously served as SportsLine's main boxing analyst and covered the sport for multiple outlets for more than 20 years. Previous SportsLine selections included Floyd Mayweather by decision (-120) over Manny Pacquiao in 2015 and Anthony Joshua by TKO/KO (-150) over Wladimir Klitschko in 2017. Anyone who has followed Nagel's combat sports picks is WAY UP! 

With Tyson Fury vs. Oleksandr Usyk 2 fast approaching, Nagel has studied the boxing match from every angle and released confident picks on the total rounds completed and method-of-victory props. 

We can tell you he likes the Under for rounds, and he's also locked in a confident money line and method-of-victory prop that brings a plus-money payout! You ABSOLUTELY need to see Nagel's picks before making any of your own!

Who wins Tyson Fury vs. Oleksandr Usyk 2, and which method of victory prop is a MUST-BACK? ... Join SportsLine here to see which bets you need to make for the fight, all from the accomplished veteran combat sports analyst who has consistently delivered winners!