The Minnesota Twins (52-39) and the Chicago White Sox (26-67) meet in Game 1 of a doubleheader on Wednesday afternoon. On Monday, Minnesota outlasted Chicago 8-6 in 11 innings, before Tuesday's game was washed away by rain.

First pitch is scheduled for 2:10 p.m. ET from Guaranteed Rate Field in Chicago. The Twins are the -164 money-line favorites (risk $164 to win $100) in the latest Twins vs. White Sox odds, while Chicago is a +137 underdog. The over/under for total runs scored is 8 in the latest MLB odds via SportsLine consensus. 

Before you make any Twins vs. White Sox picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 16 of the 2024 MLB season a profitable 49-37 on all-top rated MLB picks this season. Dating back to last season, it is on a 24-9 roll on top-rated run-line picks (+1077). Anybody following has seen STRONG returns!

The model knows shortstop Carlos Correa is among Minnesota's top hitters. In 72 games this season, he is batting .303 with 16 doubles, two triples, 12 homers, 46 RBI and 49 runs scored. He homered in the Twins' 11-inning win on Monday.

The model also knows first baseman Andrew Vaughn is among the White Sox's top hitters. In 85 games, he is batting .241 with 17 doubles, 11 homers, 43 RBI and 33 runs scored. He has hit safely in three consecutive games and in nine of the past 10.

The model has simulated Twins vs. White Sox 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

Who wins Twins vs. White Sox, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 24-9 roll on top-rated MLB run-line picks!