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Twins vs. White Sox line, odds, start time, pick, best bets for April 24 matchup from proven model

SportsLine's projection model, which is on a profitable 13-6 run, has locked in its MLB picks for the Chicago White Sox vs. Minnesota Twins at Target Field on Thursday

By@SportsLineUpdated: Apr 24, 2025 4:02PM UTC . 2 min read

The Minnesota Twins and Chicago White Sox will conclude their three-game series in Minnesota on Thursday afternoon. Minnesota is coming off a 6-3 win over the White Sox on Wednesday and will go for the sweep on Thursday. The Twins improved to 9-15 overall this season after Wednesday's victory. The White Sox fell to 5-19 overall.

First pitch from Target Field in Minneapolis, Minn., is set for 1:10 p.m. ET. Minnesota is a -225 favorite on the money line (risk $225 to win $100) in the latest White Sox vs. Twins odds, while Chicago is a +188 underdog. The over/under for total runs scored is 8 in the latest MLB odds via SportsLine consensus.

Before making any Twins vs. White Sox picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 5 of the 2025 MLB season on a 13-6 run on top-rated MLB picks (+415). Anybody following could have seen strong returns!

The model has simulated White Sox vs. Twins 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line is the better value!

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