The Los Angeles Chargers and the Tennessee Titans are set to square off in a Week 10 cross-division AFC battle at on Sunday at SoFi Stadium. Los Angeles is 5-3 overall and 2-1 at home, while Tennessee is 2-6 overall and 1-3 on the road. The Chargers have won two straight games and are coming off a 27-10 win over the Cleveland Browns. The Titans will be looking to build some momentum after notching a 20-17 overtime win over the New England Patriots in Week 9. Tennessee is 1-7 and Los Angeles is 5-2-1 against the spread this season. Will Levis (shoulder) is expected to start at quarterback for the Titans. 

Kickoff in Inglewood, Calif. is at 4:05 p.m. ET. The Chargers are favored by 7.5 points in the latest Chargers vs. Titans odds, and the over/under is 39 points. The Chargers are -397 money line favorites (risk $397 to win $100), while the Titans are +311 underdogs. Before locking in any Chargers vs. Titans picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2024 NFL season on an incredible 14-7 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 195-136 roll on top-rated NFL picks that dates back to the 2017 season and a 49-29 roll on top-rated NFL picks since Week 7 of 2022. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.

The model has simulated Chargers vs. Titans 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that hits in almost 60% of computer simulations. You can only see the pick at SportsLine.

So who wins Chargers vs. Titans? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.