The Detroit Tigers and Chicago White Sox are set to meet for a midday matchup on Friday, April 4, at Comerica Park. The game will be the home opener for the Tigers. Both teams enter with matching 2-4 records. Chicago lost two of three against the Minnesota Twins in their series leading up to Friday, while the Tigers took two of three from the Seattle Mariners in their most recent series. RHP Jonathan Cannon is expected to start for the White Sox, while RHP Jack Flaherty will be on the mound for the Tigers. 

First pitch from Comerica Park in Detroit is set for 1:10 p.m. ET. Detroit is a -253 favorite (risk $253 to win $100) on the money line in the latest White Sox vs. Tigers odds, while the total number of runs Vegas thinks will be scored, or the over/under, is 7, in the latest MLB odds via SportsLine consensus.  

Before making any White Sox vs. Tigers picks or Friday MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 2 of the 2025 MLB season on a 34-18 roll on top-rated run-line picks (+729). Anybody following could have seen strong returns!

The model has simulated White Sox vs. Tigers 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

Who wins White Sox vs. Tigers, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 34-18 roll on top-rated MLB picks!