The Minnesota Twins (4-10) host the Detroit Tigers (8-5) in a divisional tilt on Saturday afternoon. These teams collided in the first game of the series on Friday, where the Tigers won 7-6. Jackson Jobe (0-0, 5.00 ERA) starts for Detroit. Chris Paddack (0-1, 14.73 ERA) is on the mound for the Twins.

First pitch is scheduled for 2:10 p.m. ET at Target Field in Minneapolis, Minnesota. The Twins are the -144 money-line favorites (bet $144 to win $100) in the latest Tigers vs. Twins odds, while the Tigers are +122 underdogs (bet $100 to win $122). The over/under for total runs scored is 9 in the latest MLB odds, via SportsLine consensus. 

Before you make any Tigers vs. Twins picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 3 of the 2025 MLB season on a 34-19 roll on top-rated run-line MLB betting picks (+629). Anybody following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Tigers vs. Twins 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has ALL the value!

Who wins Tigers vs. Twins, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 34-19 roll on top-rated MLB run-line picks!