The third-seeded Houston Astros will look to stay alive and even their best-of-three series when they battle the sixth-seeded Detroit Tigers in American League Wild Card action on Wednesday afternoon. Detroit held on for a 3-1 win in Tuesday's series opener. The Tigers (86-76), who went 48-30 since July 1, are making their first postseason appearance since 2014, while the Astros (88-73) won the AL West for the seventh time in the last eight years, including the last four.

First pitch is scheduled for 2:30 p.m. ET from Minute Maid Park in Houston. The Astros are the -170 money line favorite (risk $170 to win $100) in the latest Tigers vs. Astros odds, while the Tigers are +143 underdogs. The over/under for total runs scored is 7.5 in the latest MLB odds via SportsLine consensus. 

Before you make any Tigers vs. Astros picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. Entering the 2024 MLB playoffs, it's on a 32-17 roll on top-rated run-line picks (+822) that dates back to last season. Anybody following has seen STRONG returns!

The model knows Houston left fielder Yordan Alvarez is off to a hot start to the playoffs. He was 2-for-4 with a double in the Game 1 loss. He finished the regular season batting .308 with 34 doubles, two triples, 35 homers, 86 RBI and 88 runs scored. In 28 career games against the Tigers, Alvarez is batting .273 with five doubles, four homers and 22 RBI.

The model also knows left fielder Riley Greene has been among Detroit's top hitters this season. In 137 regular-season games, he hit .262 with 27 doubles, six triples, 24 homers and 74 RBI with 82 runs scored. He doubled in the series opener. Greene has feasted on Astros pitching in his career. In 15 games against Houston, he is hitting .321 with two doubles, one triple, three homers and 10 RBI.

The model has simulated Tigers vs. Astros 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

Who wins Tigers vs. Astros, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 32-17 roll on top-rated MLB run-line picks!