The No. 2 seed Tennessee Volunteers will battle the No. 3 seed Kentucky Wildcats in the Sweet 16 on Friday night. Kentucky swept the season series between these SEC rivals, and it advanced to the second weekend of the NCAA Tournament with wins over Troy and Illinois. Tennessee controlled the tempo in its wins over Wofford and UCLA last weekend, advancing to its third consecutive Sweet 16 under head coach Rick Barnes. 

Tipoff from Lucas Oil Stadium in Indianapolis is set for 7:39 p.m. ET. Tennessee is a 4.5-point favorite in the latest Tennessee vs. Kentucky odds from SportsLine consensus, while the over/under for total points scored is 144.5. Tennessee is a -207 favorite on the money line.

Before making any Tennessee vs. Kentucky picks, you won't want to miss the college basketball predictions from red-hot college basketball expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. 

He's done well in college basketball, going 341-208 (62.1%) over the last three campaigns. He joined SportsLine in 2024 and promptly went 28-14-1 (67%) in college basketball picks, returning $1,215 to $100 players. He's now 60-36 (+1828) in his last 96 official college basketball plays on SportsLine. Additionally, he is 9-0 (+900) in his last nine picks in Kentucky games. Anybody who's followed his advice is WAY UP!

For Tennessee vs. Kentucky, Casale is leaning Over on the total and he also found a critical x-factor that has has him jumping on one side of the spread. You ABSOLUTELY NEED to see these picks before locking in any 2025 NCAA Tournament picks of your own.

So who wins Tennessee vs. Kentucky and which side of the spread should you back? Join SportsLine right now to see which side of the spread you need to jump on, all from a red-hot college basketball expert that is on a 60-36 (+1828) run on his NCAA hoops picks!