We've got another exciting Western Conference matchup on Wednesday's NBA schedule as the San Antonio Spurs will host the Los Angeles Lakers. San Antonio is 10-8 overall and 8-3 at home, while Los Angeles is 10-7 overall and 3-5 on the road. The Lakers have won seven of the last eight meetings, including a 120-115 victory on Nov. 15.

Tipoff is at 8:30 p.m. ET at Frost Bank Center in San Antonio. Los Angeles is favored by 2.5 points in the latest Lakers vs. Spurs odds, per SportsLine consensus, and the over/under is 228 points. Before entering any Spurs vs. Lakers picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 6 of the 2024-25 NBA season on a sizzling 114-76 roll on all top-rated NBA picks dating back to last season, returning more than $3,000. Anyone following has seen HUGE returns!

The model has simulated Lakers vs. Spurs 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that hits almost 60% of the time. You can only see the pick at SportsLine.

So who wins Spurs vs. Lakers, and which side of the spread hits in almost 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks.