The San Antonio Spurs (23-28) and the Boston Celtics (38-16) collide in a cross-conference battle on Wednesday. On Monday, Boston blew out the Miami Heat 103-85. The Spurs just snapped their two-game losing streak as San Antonio defeated the Washington Wizards 131-121 on Monday. The Celtics have defeated the Spurs in each of their last four matchups, with a 25.3-point average margin of victory over this stretch. Jrue Holiday (shoulder) is out, while Jaylen Brown (knee) is questionable for Boston.

Tipoff from TD Garden in Boston is set for 7 p.m. ET. San Antonio owns a 58-45 edge over Boston in the all-time series but the Celtics won the last game against the Spurs when it topped Boston topped San Antonio 117-98 on Jan. 17. Additionally, Boston has defeated the Spurs in four straight meetings. The Celtics are 8.5-point favorites in the latest Spurs vs. Celtics odds from SportsLine consensus, while the over/under for total points is 234.5. Boston is at -356 on the money line (risk $356 to win $100), while San Antonio is at +281 (risk $100 to win $281).

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