The 2024-25 college basketball season begins on Monday when Southern Illinois faces Charleston in The Field of 68 Opening Day Showcase. The event, which is being hosted by the Sanford Pentagon in South Dakota, also features Saint Louis vs. Santa Clara and McNeese State vs. South Dakota State later in the day. Charleston is in its first season under head coach Chris Mack, while Southern Illinois head coach Scott Nagy is also in his first season. 

Tipoff is set for noon ET on Monday at Sanford Pentagon in Sioux Falls, South Dakota. Charleston is favored by 3.5 points in the latest Southern Illinois vs. Charleston odds, while the over/under is 146.5 points, per SportsLine consensus. Before entering any Charleston vs. Southern Illinois picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2024-25 season on a 153-110 roll (+1891) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

The model has simulated Southern Illinois vs. Charleston 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 60% of simulations!

So who wins Charleston vs. Southern Illinois, and which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!