Teams looking to get back into the win column clash when the South Carolina Gamecocks tangle with the Vanderbilt Commodores in Southeastern Conference action on Wednesday. South Carolina is coming off a 66-63 loss to Auburn on Saturday, while Vanderbilt dropped a 75-66 decision at Missouri that same day. The Gamecocks (10-6, 0-3 SEC), who have lost three in a row, are 1-2 on the road this season. The Commodores (13-3, 1-2 SEC), who have lost two straight, are 8-1 on their home court.

Tip-off from Memorial Gymnasium in Nashville, Tenn., is set for 6 p.m. ET. Vanderbilt is a 7.5-point favorite in the latest South Carolina vs. Vanderbilt odds from SportsLine consensus, while the over/under for total points scored is set at 143.5.

Before entering any South Carolina vs. Vanderbilt picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 11 of the 2024-25 season on a 195-134 roll (+2882) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated South Carolina vs. Vanderbilt 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins South Carolina vs. Vanderbilt, and which side of the spread hits in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!