The Seattle Seahawks will take on the Detroit Lions at 4:25 p.m. ET on Sunday at Lumen Field. The Seahawks are 5-10 overall and 2-5 at home, while Detroit is 2-12-1 overall and 0-7-1 on the road. Seattle is ranked fourth in the NFC West; the Lions are ranked fourth in the NFC North. 

Seattle is favored by 6.5 points in the latest Seahawks vs. Lions odds from Caesars Sportsbook, while the over-under is set at 42.5. Before you make any Lions vs. Seahawks picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up over $7,100 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 17 of the 2021 season on an incredible 134-96 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has simulated Seahawks vs. Lions 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Seahawks vs. Lions? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.