The Week 8 NFL schedule features a cross-conference matchup between the Buffalo Bills (5-2) and the Seattle Seahawks (4-3) on Sunday at Lumen Field in Seattle. The Bills are 2-2 on the road and the Seahawks are 2-2 at home. Buffalo is coming off a 34-10 blowout win over the Tennessee Titans in Week 7, while Seattle is looking to build off an impressive 34-14 road win over the Atlanta Falcons. The Bills are 4-3 and the Seahawks are 2-4-1 against the spread in 2024. 

Kickoff is at 4:05 p.m. ET. The Bills are favored by 3 points in the latest Seahawks vs. Bills odds from SportsLine consensus, and the over/under is 48 points. Buffalo is a -155 money-line favorite (risk $155 to win $100). Before locking in any Bills vs. Seahawks picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 8 of the 2024 NFL season on an incredible 12-5 hot streak on top-rated NFL picks this year. Longer term, it is on a 193-134 roll on top-rated NFL picks that dates back to the 2017 season and a 47-27 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

The model has simulated Seahawks vs. Bills 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that has all the value. You can only see the model's pick at SportsLine.

So who wins Bills vs. Seahawks? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.