The Cal Poly Mustangs will start their season against the San Francisco Dons on Tuesday. Cal Poly is coming off a 4-28 season, while the Dons went 23-11. San Francisco made the NIT but lost its first game to Cincinnati in overtime.

Tip off is scheduled at 10 p.m. ET at War Memorial Gymnasium in San Francisco. The Dons are favored by 22 points in the latest Cal Poly vs. San Francisco odds, per SportsLine consensus. The over/under is 149.5 points. Before entering any San Francisco vs. Cal Poly picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters the 2024-25 season on a 153-110 roll (+1891) on all top-rated college basketball picks dating back to 2023. Anyone following has seen huge returns.

The model has simulated San Francisco vs. Cal Poly 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 60% of simulations!

So who wins Cal Poly vs. San Francisco, and which side of the spread hits in well over 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!