The Week 10 NFL schedule features a cross-conference matchup between the New Orleans Saints (3-6) and the Pittsburgh Steelers (2-6) at Acrisure Stadium in Pittsburgh. The Saints are hoping to bounce back from a disappointing 27-13 loss to the Baltimore Ravens on Monday Night Football, while the Steelers are coming off a bye in Week 9 and looking to snap a two-game losing streak. Pittsburgh is 3-4-1 against the spread, while New Orleans is 3-6 ATS in 2022.

Kickoff is at 1 p.m. ET. The latest Steelers vs. Saints odds from Caesars Sportsbook list this game as a pick'em, and the over/under is set at 39.5. Before making any Steelers vs. Saints picks or predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2022 NFL season on an incredible 151-108 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Steelers vs. Saints 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits over 50% of the time. You absolutely need to see it before locking in your own picks.

So who wins Saints vs. Steelers? And which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.