The New Orleans Saints (1-3) host Geno Smith and the Seattle Seahawks (2-2) at 1 p.m. ET on Sunday at Caesars Superdome. The Saints have a lengthy injury report with running back Alvin Kamara, safety Marcus Make, guard Andrus Peat, wide receiver Michael Thomas, and quarterback Jameis Winston all listed as questionable. New Orleans is coming off a tough 28-25 loss to the Minnesota Vikings in London, while the Seahawks won a shootout against the Detroit Lions 48-45 in Week 4. 

New Orleans is favored by 5 points in the latest Seahawks vs. Saints odds from Caesars Sportsbook, and the over/under is set at 45 points. Before making any Saints vs. Seahawks picks or predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2022 NFL season on an incredible 140-105 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Saints vs. Seahawks 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits over 50% of the time. You absolutely need to see it before locking in your own picks.

So who wins Saints vs. Seahawks? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.