The Week 8 NFL schedule features a cross-conference matchup between the New Orleans Saints (2-5) and the Los Angeles Chargers (3-3) on Sunday at SoFi Stadium in Inglewood, California. The Saints are 1-2 on the road and the Chargers are 1-1 at home. New Orleans is looking to bounce back from a 33-10 blowout loss to the Denver Broncos on Thursday Night Football, while the Chargers are aiming to rebound from a 17-15 loss against the Arizona Cardinals on Monday Night Football The Saints are 3-4 and the Chargers are 3-2-1 against the spread in 2024. 

Kickoff is at 4:05 p.m. ET. The Chargers are favored by 7 points in the latest Chargers vs. Saints odds from SportsLine consensus, and the over/under is 41 points. Los Angeles is a -337 money-line favorite (risk $337 to win $100). Before locking in any Saints vs. Chargers picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 8 of the 2024 NFL season on an incredible 12-5 hot streak on top-rated NFL picks this year. Longer term, it is on a 193-134 roll on top-rated NFL picks that dates back to the 2017 season and a 47-27 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

The model has simulated Saints vs. Chargers 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread is the better value!

So who wins Saints vs. Chargers in Week 8, and which side of the spread is the better value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks!