The No. 7 seed Saint Mary's Gaels will face the No. 10 seed Vanderbilt Commodores in the first round of the 2025 NCAA Tournament on Friday afternoon. Saint Mary's won the West Coast Conference regular-season title, but it lost to Gonzaga in the WCC Tournament title game. Vanderbilt was one of 14 SEC teams included in the NCAA Tournament field after finishing ninth in the regular-season standings.  

Tipoff from Rocket Arena in Cleveland is set for 3:15 p.m. ET. The Gaels are 4.5-point favorites in the latest Saint Mary's vs. Vanderbilt odds, via SportsLine consensus, while the over/under for total points is 136.5.

Before making any Saint Mary's vs. Vanderbilt picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Saint Mary's vs. Vanderbilt 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread cashes in well over 50% of simulations!

So who wins Saint Mary's vs. Vanderbilt, and which side of the spread cashes in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!