The Boston Red Sox continue their tradition of playing a home game on Patriots' Day morning on Monday when they host the Chicago White Sox at Fenway Park. The Red Sox have been scheduled to play a home game on Patriots' Day every year since 1959 and have started the contest at 11:10 a.m. every year since 1968 to allow people to also witness the Boston Marathon later that day. Monday is the final contest of a four-game series with Boston winning two of the first three games.

First pitch from Fenway Park in Boston, Mass., is set for 11:10 a.m. ET. Boston is a -290 favorite on the money line (risk $291 to win $100) in the latest White Sox vs. Red Sox odds, while Chicago is a +235 underdog. The over/under is 9 runs scored in the latest MLB odds via SportsLine consensus.

Before making any Red Sox vs. White Sox picks or MLB predictions for Patriots' Day, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 4 of the 2025 MLB season on an 8-3 run on top-rated money-line picks (+340). Anybody following could have seen strong returns!

The model has simulated White Sox vs. Red Sox 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line is the better value!

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