The Boston Red Sox continue their season-opening six-game road trip when they visit the Detroit Tigers on Tuesday for the middle contest of their three-game series. First pitch at Comerica Park is set for 1:10 p.m. ET.

Boston is listed as a -125 favorite (risk $125 to win $100) on the money line in the latest Red Sox vs. Tigers odds from Caesars Sportsbook, while the over-under for total runs scored is nine (see the latest lines for every game on our MLB odds page).

Before making any Tigers vs. Red Sox picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters Week 2 of the 2022 season on a 216-181 roll on top-rated MLB money-line picks that dates back to last season, returning over $900 for $100 players. Anyone following it has seen HUGE returns!

The model knows Boston sends veteran Rich Hill to the mound Tuesday for his first start of 2022 after going 7-8 with a 3.86 ERA in 32 games with Tampa Bay and the New York Mets last year. The 42-year-old left-hander posted a 4-1 record and 1.34 ERA over 44 contests (four starts) in two previous stints with the Red Sox. Comerica Park is a favorite of J.D. Martinez, who spent 3 1/2 seasons with the Tigers and entered the season with a .315 batting average, 59 home runs and 166 RBIs at the stadium.

The model also knows Tyler Alexander will be making his first career start against the Red Sox. In two relief appearances versus the club, the 27-year-old southpaw allowed six hits and four runs - three earned - with four strikeouts over four innings. One of Detroit's better hitters against Boston is Jeimer Candelario, who entered this season batting .348 with four homers and 14 RBIs in 18 career meetings.

Now, it has set its sights on Red Sox vs. Tigers. We can tell you the model is projecting 10.1 total runs, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Red Sox vs. Tigers? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the Tigers vs. Red Sox money line you should be all over on Tuesday, all from the model that has gone 216-181 on top-rated MLB money-line picks dating back to last season!