The Buffalo Bills and the Los Angeles Rams are set to square off in an NFC battle on Sunday at SoFi Stadium. Buffalo is 10-2 overall and 4-2 on the road, while Los Angeles is 6-6 overall and 3-3 at home. The Bills are riding a seven-game winning streak, and are coming off a 35-10 blowout win over the San Francisco 49ers on Sunday Night Football in Week 13. The Rams are looking to build off their 21-14 win over the New Orleans Saints and keep pace in the NFC playoff race. The Bills are 8-4, while the Rams are 5-7 against the spread this season.

Kickoff in Inglewood, Calif. is at 4:25 p.m. ET. The Bills are favored by 4 points in the latest Bills vs. Rams odds via SportsLine consensus, and the over/under is 49 points. Buffalo is a -207 money line favorite (risk $207 to win $100), while Los Angeles is a +173 underdog. Before locking any Bills vs. Rams picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 14 of the 2024 NFL season on an incredible 24-10 hot streak on top-rated NFL picks this year. Longer term, it is on a 204-138 roll on top-rated NFL picks that dates back to the 2017 season and a 58-31 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

The model has simulated Rams vs. Bills 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You can only see the model's pick at SportsLine.

So who wins Bills vs. Rams? And which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks!