The Los Angeles Rams and San Francisco 49ers will meet in a key NFC West matchup on Thursday Night Football. Los Angeles, which beat San Francisco 27-24 in Week 3, will try to sweep the season series with the 49ers for the first time since 2018. The Rams (7-6), second in the NFC West, are coming off a 44-42 win over the Buffalo Bills. The 49ers (6-7), tied for third in the division with the Arizona Cardinals, downed the Chicago Bears, 38-13, last Sunday.

Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8:15 p.m. ET. The 49ers are 2.5-point favorites in the latest Rams vs. 49ers odds, while the over-under for total points scored is 48.5. The 49ers are -140 money-line favorites (risk $140 to win $100), while the Rams are +119 underdogs (risk $100 to win $119).

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