A Big Ten battle is on tap between the No. 1 Purdue Boilermakers and the Penn State Nittany Lions at 6:30 p.m. ET Wednesday at Mackey Arena. The Boilermakers are 21-1 overall and 10-1 at home, while Penn State is 14-7 overall and 1-4 on the road. Purdue is ranked first in the Big Ten; Penn State is ranked ninth.

The Boilermakers are favored by 10 points in the latest Purdue vs. Penn State odds from Caesars Sportsbook, and the over/under is set at 135. Before you make any Penn State vs. Purdue picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 13 of the season 50-29 on all-top rated college basketball picks, returning more than $1,200 for $100 players. Anybody who has followed it has seen huge returns.

Now, it has simulated Purdue vs. Penn State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Purdue vs. Penn State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!