The No. 10 Purdue Boilermakers will try to remain in second place in the Big Ten standings when they host the Indiana Hoosiers on Friday night. Purdue has won eight of its last nine games, including a 91-64 win over then-No. 21 Michigan last Friday. Indiana has lost four of its last five games, most recently falling to Maryland in a 79-78 heartbreaker on Sunday.  

Tip-off is set for 8 p.m. ET on Friday at Mackey Arena. Purdue is favored by 12.5 points in the latest Purdue vs. Indiana odds, while the over/under is 146 points per SportsLine consensus. 

Before entering any Indiana vs. Purdue picks, you'll want to see the NCAA basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 13 of the 2024-25 season on a 202-142 betting roll (+2468) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has simulated Purdue vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that says one side of the spread hits more than 50% of the time!

So who wins Purdue vs. Indiana, and which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!