The No. 1 seed Houston Cougars and the No. 4 seed Purdue Boilermakers are set to battle in the Sweet 16 Friday. The Cougars took out Gonzaga 81-76 in the second round. As for the Boilermakers, they defeated McNeese 76-62 on March 22. The winner will play No. 2 seed Tennessee or No. 3 seed Kentucky in the Elite Eight. 

Tipoff from the Lucas Oil Stadium in Indianapolis, Indiana, is set for 10:09 p.m. ET. Houston is an 8.5-point favorite in the latest Purdue vs. Houston odds from SportsLine consensus, while the over/under for total points scored is 134.5. The Cougars are -441 money-line favorites. 

Before making any Purdue vs. Houston picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-168 roll (+1815) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and has nailed 25 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Purdue vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Purdue vs. Houston, and which side of the spread hits in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-168 (+1815) on top-rated college basketball pick and has nailed 24 double-digit upsets!