The Pittsburgh Panthers will take on the Massachusetts Minutemen at 4 p.m. ET on Saturday, June 4 at Heinz Field. UMass is coming off an 0-4 season in 2020, while Pitt ended the 2020 college football season with a 6-5 overall record. 

The Panthers are favored by 38 points in the latest Pittsburgh vs. Massachusetts odds from Caesars Sportsbook, and the over-under is set at 56. Before you make any Massachusetts vs. Pittsburgh picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Pittsburgh vs. Massachusetts 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Pittsburgh vs. Massachusetts? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks ...If you're already a member, see the picks below!