The Detroit Pistons will host the San Antonio Spurs in a cross-conference matchup on Tuesday's NBA schedule. Detroit is 40-32 overall and 19-16 at home, while San Antonio is 31-39 overall and 12-22 on the road. The Pistons won the lone matchup earlier this season, 125-110, on the road on Feb. 21.

Tipoff is at 7 p.m. ET at the Little Caesars Arena in Detroit, where the home team is 19-16 this season. The Pistons are favored by 10.5 points in the latest Spurs vs. Pistons odds, per SportsLine consensus. The over/under is 233.5 points, which is an increase from opening at 228.5. Detroit is at -495 on the money line (risk $495 to win $100), while San Antonio is at +374 (risk $100 to win $374). Before entering any Pistons vs. Spurs picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 23 of the 2024-25 NBA season on a sizzling 153-113 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It's also an outstanding 20-10 (67%) on top-rated spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Pistons vs. Spurs 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

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