The Detroit Pistons will host the San Antonio Spurs in a cross-conference NBA matchup on Wednesday. Detroit is 3-34 overall and 2-15 at home, while San Antonio is 5-30 overall and 3-15 on the road. These teams have alternated wins and losses over their last four meetings, with the home team winning each time.

Tip-off is at 7 p.m. ET at Little Caesars Arena in Detroit. San Antonio is favored by 2.5 points in the latest Pistons vs. Spurs odds, per SportsLine consensus, and the over/under is 238 points. Before entering any Spurs vs. Pistons picks, you'll want to see the NBA predictions from the model at SportsLine.

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The model has simulated Pistons vs. Spurs 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that hits well over 50% of the time. You can only see the pick at SportsLine.

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