We've got another exciting Eastern Conference matchup on the Wednesday NBA schedule as the Detroit Pistons and the Boston Celtics are set to battle at Little Caesars Arena. Detroit is 32-26 overall and 15-13 at home, while Boston is 42-16 overall and 24-6 on the road. The Celtics are riding a six-game winning streak after beating the Toronto Raptors 111-101 on Tuesday. The Pistons have won seven straight, and are coming off a 106-97 win over the Los Angeles Clippers on Monday.

Tipoff is scheduled for 7 p.m. ET. The Celtics are favored by 5 points in the latest Pistons vs. Celtics odds, and the over/under is 226.5 points. Before making any Pistons vs. Celtics picks, you'll want to see the NBA predictions and betting advice from the proven computer simulation model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 19 of the 2024-25 NBA season on a sizzling 147-106 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It's also an outstanding 18-10 (64%) on top-rated spread picks this season. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has simulated Pistons vs. Celtics 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations!

So who wins Pistons vs. Celtics, and which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks!