We've got another exciting Central Division matchup on Wednesday's NBA schedule as the Detroit Pistons will host the Cleveland Cavaliers. Detroit is 25-25 overall and 12-12 at home, while Cleveland is 40-10 overall and 16-6 on the road. The Cavs have defeated the Pistons in 11 straight games, including a 110-91 victory on Jan. 27.

Tipoff is at 7 p.m. ET at the Little Caesars Arena in Detroit. Cleveland is favored by 5.5 points in the latest Cavaliers vs. Pistons odds, per SportsLine consensus, and the over/under is 238.5 points. Before entering any Pistons vs. Cavaliers picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 16 of the 2024-25 NBA season on a sizzling 144-102 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. Anyone following at sportsbooks and on betting apps could have seen HUGE returns!

The model has simulated Pistons vs. Cavaliers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Cavaliers vs. Pistons, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks.