We've got another exciting Eastern Conference matchup on the NBA schedule as the Detroit Pistons and the Philadelphia 76ers are set to tip at 7 p.m. ET on Wednesday at Little Caesars Arena. Detroit is 2-21 overall and 1-11 at home, while Philadelphia is 15-7 overall and 6-4 on the road. The 76ers are favored by 12 points in the latest Pistons vs. 76ers odds, and the over/under is 233 points.

Before entering any Pistons vs. 76ers picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past five-plus seasons. The model enters Week 8 of the 2023-24 NBA season on a sizzling 97-51 roll on all top-rated NBA picks dating back to last season, returning more than $4,000. Anyone following it has seen huge returns.

The model has simulated Pistons vs. 76ers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations. 

So who wins Pistons vs. 76ers? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks. If you're already a member, see the picks below!