The Chicago Cubs (16-10) host Philadelphia Phillies (13-12) in the first contest of a three-game series on Friday. The Phillies are on a four-game skid, falling 4-3 to the New York Mets on Wednesday. Meanwhile, the Cubs topped the Los Angeles Dodgers 7-6 in their last outing. 

First pitch is scheduled for 2:20 p.m. ET at Wrigley Field in Chicago. The Cubs are the -158 money-line favorites (bet $158 to win $100) in the latest Phillies vs. Cubs odds, while the Phillies are +133 underdogs (bet $100 to win $133). The over/under for total runs scored is 8 in the latest MLB odds. 

Before you make any Phillies vs. Cubs picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 5 of the 2025 MLB season on a 13-6 run on top-rated MLB picks (+415). Anybody following could have seen strong returns!

The model has simulated Phillies vs. Cubs 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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