The Chicago Cubs will look to earn the series win when they battle the Philadelphia Phillies in the second of a three-game series on Saturday. The Phillies (13-13), who have lost five in a row, are just 4-9 on the road this season. The Cubs (17-10), who have won three straight, are 9-5 on their home field.

First pitch from Wrigley Field in Chicago is set for 4:05 p.m. ET. Philadelphia is a –111 favorite on the money line (risk $111 to win $100) in the latest Phillies vs. Cubs odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 7. Before making any Phillies vs. Cubs picks, or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 5 of the 2025 MLB season on a 13-6 run on top-rated MLB picks (+415). Anybody following could have seen strong returns!

The model knows Chicago is expected to send right-hander Ben Brown (2-1, 4.57 ERA) to the mound. In his last outing, he received a no-decision in a 6-2 win over the Arizona Diamondbacks on April 19. In that game, he pitched four innings, allowing one earned run and four walks, while striking out six. In a 16-0 win over the Los Angeles Dodgers on April 12, he pitched six innings, allowing five hits, while striking out five. He is facing Philadelphia for the first time in his career.  

The model also knows Philadelphia will counter with left-hander Jesus Luzardo (2-0, 2.08 ERA). The seven-year veteran has been solid in five starts so far in 2025, allowing just 26 hits, seven earned runs and seven walks with 36 strikeouts in 30.1 innings. He received a no-decision in his last outing, a 7-5 loss to the Miami Marlins on Sunday. In that game, he pitched seven innings, allowing eight hits, two runs – one earned – with seven strikeouts.

The model has simulated Phillies vs. Cubs 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side has ALL the value!

Who wins Phillies vs. Cubs, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on an 13-6 run on top-rated MLB picks!