The Houston Astros will look to close out their series with the Philadelphia Phillies when they meet in Game 6 of the 2022 World Series. With a win, the Astros (106-56) will secure their second-ever World Series Championship, and first since beating the Los Angeles Dodgers 4-3 in 2017. This is Houston's second consecutive World Series appearance and fourth in six seasons. The Phillies (87-75) need two wins to win their first World Series since defeating the Tampa Bay Rays 4-1 in 2008. This is Philadelphia's third World Series appearance in 15 years.

First pitch from Minute Maid Park in Houston is set for 8:03 p.m. ET. Houston is listed as a -145 favorite (risk $145 to win $100) on the money line in the latest Phillies vs. Astros odds from Caesars Sportsbook, while the over/under for total runs scored is 7 (see the latest lines for every game on our MLB odds page).

Before making any Phillies vs. Astros picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the 2022 World Series on a 20-13 roll on top-rated MLB money-line picks, returning more than $400. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen HUGE returns!

The model knows Houston is expected to send left-hander Framber Valdez (17-6, 2.82 ERA) to the mound. He is 2-0 with a 1.42 ERA this postseason. He picked up the win in Game 2, allowing just four hits, one earned run and three walks, while striking out nine in 6 1/3 innings. He has been sharp in all three playoff appearances, allowing just three earned runs on 12 hits in 19 innings.

The model also knows Philadelphia is expected to start right-hander Zach Wheeler (12-7, 2.82 ERA). He took the loss in Game 2, allowing four earned runs on six hits with three walks and three strikeouts in six innings. He was outstanding in a 2-0 Game 1 win over the San Diego Padres in the American League Championship Series. In that contest, he allowed just one hit and one walk, while striking out eight in seven innings of work. This will be his first appearance against the Astros.

Now, it has set its sights on Phillies vs. Astros. We can tell you the model is leaning Over on the total, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins World Series Game 6 Phillies vs. Astros? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Phillies vs. Astros run line you should be all over on Saturday, all from the model on a roll on MLB picks!