Big Ten basketball is back and two programs off to great starts will begin conference play on Thursday when the Penn State Nittany Lions host the No. 8 Purdue Boilermakers. Penn State and Purdue are both 7-1 on the season and the Nittany Lions' signature win to date was at a neutral site against Virginia Tech while Purdue had a home win over Alabama and neutral court wins over NC State and Ole Miss. The Boilermakers have won nine of the last 10 head-to-head meetings with Penn State, but the Nittany Lions are 6-4 against the spread during that span.

Tipoff is scheduled for 6:30 p.m. ET at the Bryce Jordan Center in State College, Penn. The Nittany Lions are 1.5-point favorites in the latest Penn State vs. Purdue odds from SportsLine consensus, while the over/under for total points scored is 149.5. Before entering any Purdue vs. Penn State picks, you'll want to see the NCAA basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 4 of the 2024-25 season on a 170-123 roll (+2061) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

The model has simulated Penn State vs. Purdue 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick where one side of the spread hits nearly 70% of the time!

So who wins Purdue vs. Penn State, and which side of the spread hits nearly 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!