The No. 6 seed Penn State Nittany Lions and No. 7 seed Notre Dame Fighting Irish will square off in the College Football Playoff semifinals on Thursday night with a national championship berth at stake in the Orange Bowl. Penn State is coming off blowout wins over No. 11 seed SMU and No. 3 seed Boise State, while Notre Dame beat No. 10 seed Indiana before taking down No. 2 seed Georgia. This is the first meeting between the Fighting Irish and Nittany Lions since 2007.    

Kickoff is set for 7:30 p.m. ET on Thursday at Hard Rock Stadium in Miami. Notre Dame is favored by 1.5 points in the latest Penn State vs. Notre Dame odds, while the over/under is 46.5 points, per SportsLine consensus. Notre Dame is the -129 favorite (risk $129 to win $100) on the money line.

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The model has simulated Penn State vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations!

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