The New England Patriots will visit the Buffalo Bills in a key Monday Night Football matchup. Kickoff at Highmark Stadium in Orchard Park, N.Y., is set for 8:15 p.m. ET. The Bills are favored by three points in the latest Patriots vs. Bills odds from Caesars Sportsbook, while the over-under is 40.5.

Before you make any Patriots vs. Bills picks or any other NFL predictions, you NEED to see which side Larry Hartstein, SportsLine's top NFL expert, is on. 

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Entering the 2021 campaign, Hartstein was 351-291 all-time on NFL sides, including 326-280 against the spread. He is returning more than $2,200 for $100 bettors and is SportsLine's No. 1 NFL expert on a 53-26 roll. Anyone who has followed him is WAY UP.

Hartstein knows that despite some recent struggles, Buffalo remains one of the top scoring teams in the league, averaging 29.6 points per game. Quarterback Josh Allen leads the team, completing 274-of-410 passes (66.8 percent) for 3,071 yards and 25 touchdowns. He has been picked off 10 times, but has a rating of 99.1. He is also second on the team in rushing, carrying 69 times for 383 yards (5.6 average) and three touchdowns.

Hartstein also knows New England has been on a roll due in part because of the play of rookie quarterback Mac Jones. He continues to impress, as he has completed 268-of-381 passes (70.3 percent) for 2,850 yards and 16 touchdowns. He has been intercepted eight times, but has a rating of 97.1. Jones was dominant in the win over Tennessee last Sunday, completing 23-of-32 passes for 310 yards and two touchdowns.

Now, Hartstein has locked in another confident against the spread pick for Patriots vs. Bills. We can tell you he's leaning over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Patriots vs. Bills on Monday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Patriots vs. Bills spread to jump on, all from SportsLine's top NFL expert!